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Nita Seibel, M.D.
NCI-COG Pediatric MATCH Trial: Treatment Determined by Tumor Targets
April 26, 2018
12:00 PM - 1:30 PM US Eastern Time
NIH Neuroscience Center Building, 6001 Executive Blvd, Room B1/B2, Rockville, MD

Webinar Description

Although improvements have been seen in the outcome for children and adolescents with cancer over the past 4 decades, challenges remain for treatment and the ultimate goal of curing all pediatric patients. Precision medicine trials have been ongoing in medical oncology but not to the same extent in pediatric oncology. NCI-COG Pediatric Molecular Analysis for Therapy Choice (Pediatric MATCH) is a nationwide trial to explore whether targeted therapies can be effective for children and adolescents with solid tumors that harbor specific genetic mutations and have progressed during or after standard therapy. The National Cancer Institute and the Children’s Oncology Group [a member of the NCI’s National Clinical Trials Network (NCTN)]  developed the protocol with input from the FDA and pharmaceutical companies. This is the first pediatric precision medicine trial of this scale that is being done in pediatric oncology. Despite having the NCI MATCH trial as a model, numerous challenges were encountered unique to this patient population in developing a trial and will be discussed during the presentation.

Learning Objectives

  • Describe how a biomarker-driven trial using investigational agents can be done in children and adolescents with recurrent/refractory solid tumors.
  • Identify the differences between the NCI MATCH trial and the NCI-COG Pediatric MATCH trial.
  • Delineate how the NCI-COG Pediatric MATCH trial will facilitate research and provide a better understanding of the genomic landscape of recurrent/refractory solid tumors occurring in children and adolescents.

Presenter Bio

Seibel_CVENTNita Seibel, M.D., a board certified pediatric hematologist-oncologist is the head of the Pediatric Solid Tumor Therapeutics in the Clinical Investigations Branch of the Cancer Therapy and Evaluation Program of the National Cancer Institute. Dr. Seibel received her medical degree from Ohio State University College of Medicine and Public Health and completed her residency in pediatrics at Ohio State University/Nationwide Children’s Hospital. She joined the faculty of George Washington University School of Medicine and Public Health and Children’s National Medical Center in pediatric hematology/oncology after completing her fellowship on the Pediatric Oncology Branch of the National Cancer Institute. During her 20 years as an attending physician at Children’s National Medical Center, she held numerous positions which included Solid Tumor Director, Hematology/Oncology Fellowship Training Program Director, Outreach Services Director for the Department of Hematology/Oncology, and Principal Investigator for the Children’s Oncology Group as well as Professor of Pediatrics at George Washington University School of Medicine. In addition to her role in the development of the extramural Pediatric Solid Tumor Program which includes co-chairing the NCI Pediatric MATCH study, she is also the scientific liaison for the Childhood Cancer Survivor Study and NCI Pediatric Central Institutional Review Board, co-chairs the Trans-NCI Adolescent and Young Adult Working Group and a member of the Editorial Board for the NCI Physician Data Query (PDQ) Pediatric Board. Dr. Seibel has published over 100 articles, 80 abstracts, and numerous book chapters.

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