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Programme overview - under update

  • Wednesday, 23 April, 2014
  • 08:15  -  13:00
    REGISTRATION, MOUNTING OF POSTERS
     

    Satellite

    10:00  -  12:00
    Satellite Workshop - Drug Disease Model Resource (DDMoRe)
    DDMoRe is running a 2 hours hands-on workshop on Wednesday 23rd April 2014 as an introduction to the current functionalities of its new Drug & Disease Model Library and its Modelling and Simulation (M&S) platform.
    Workshop announcement
    13:00  -  13:15
    Welcome and opening
    Session 1: Setting the scene – introduction of the concept “systems pharmacology”
    13:15  -  14:00
    Keynote lecture:
    The cellular uptake of pharmaceutical drugs is carrier mediated and is thus a problem not of biophysics but of systems biology
    Keynote Speaker:
    14:00  -  14:40
    Systems pharmacology - how did we get here?
    Speaker:
    14:40  -  15:15
    Computational immunology and its application toward systems pharmacology
    15:15  -  15:45
    Break
    Session 2: Discovery biology modeling – chemical biology as the basis for the design of new molecule
    15:45  -  16:25
    A metabolic code for signaling
    Speaker:
    16:25  -  17:05
    Target binding kinetics as determinant of pharmacology – towards optimal efficacy-safety
    Speaker:
    17:05  -  17:45
    Phenotypic screening – the use of zebrafish in drug discovery
    Speaker:
    17:45  -  18:00
    Break
    Interactive Free Communication Session
    Selected oral presentations by young scientists (4 presentations of 15 minutes)
    18:00  -  19:00
    Selected oral presentations by young scientists (4 presentations of 15 minutes)
    18:00  -  18:15
    Quantitative systems pharmacology model for LDL cholesterol lowering by anti-PCK9
    Speaker:
    18:15  -  18:30
    Insulin signaling in type 2 diabetes – experimental and modeling analyses reveal mechanisms
    of insulin resistance in human adipocyte
    Speaker:
    18:30  -  18:45
    Characterization and prediction of cardiovascular effects of fingolimod and siponimod using
    a systems pharmacology modeling approach
    Speaker:
    18:45  -  19:00
    Understanding signalling pathways through Bayesian networks: how two combined bronchodilators
    work inside the cell
    Speaker:
    19:00  -  20:30
    Poster presentations
    20:30  -  23:30
    Informal Discussions and Dinner Buffet
  • Thursday, 24 April, 2014
  • Session 3: Target exposure - systems pharmacology of drug disposition
    08:30  -  09:10
    Systems pharmacology of membrane transporters and drug disposition
    Speaker:
    09:10  -  09:50
    Physiologically-based pharmacokinetic modelling – towards the prediction of target exposure
    Speaker:
    09:50  -  10:20
    Break
    Session 4: Pathways - merging systems pharmacology with pharmacodynamics
    10:20  -  11:00
    Systems pharmacology of receptor signalling
    11:00  -  11:30
    Merging systems pharmacology with pharmacodynamics: “enhanced pharmacodynamic models"
    Speaker:
    11:30  -  12:00
    Systems pharmacology approach to Alzheimers’s disease
    Speaker:
    12:00  -  12:30
    Systems Pharmacology for prediction of drug toxicity
    Speaker:
    12:30  -  13:30
    Lunch
    Session 5: Multi-scale modeling – modeling of disease processes and disease progression
    Moderator:
    13:30  -  14:00
    Multiscale disease systems modelling
    Speaker:
    14:00  -  14:30
    Modelling of immunology for the treatment of multiple sclerosis
    Speaker:
    14:30  -  15:00
    The virtual liver network: translating from the bench to the bedside
    Speaker:
    15:00  -  15:30
    Break
    Session 6: Big Data – genomics and metabolomics in systems pharmacology
    Moderator:
    15:30  -  16:10
    Systems pharmacology: network analysis to reveal multiscale mechanisms of drug action
    Speaker:
    16:10  -  16:50
    Biomarkers: integrating genomics, proteomics and metabolomics for pathway analysis in oncology
    Speaker:
    16:50  -  17:30
    The integration of “omics” into genome-wide analysis:
    prediction of drug dose in a minority population
    Speaker:
    18:00  -  23:00
    Conference Dinner in the "Keukenhof" Castle
    including presentation of the prizes for the best oral communication and the best poster
  • Friday, 25 April, 2014
  • Session 7: Patients
    08:30  -  09:10
    Systems pharmacology - a paradigm for personalized medicine at the extremes of age?
    Speaker:
    09:10  -  09:50
    Disease modelling – scaling from intermediate (biomarker) response to clinical effect
    Speaker:
    09:50  -  10:30
    Systems pharmacology – a novel approach to the prediction of clinical outcome?
    Speaker:
    10:30  -  11:00
    Break
    Session 8: “Implementation”: industrial and regulatory aspects
    Moderator:
    11:00  -  11:30
    Systems pharmacology – industry perspective
    Speaker:
    11:30  -  12:00
    Systems pharmacology in drug regulation: the FDA view
    Speaker:
    12:01  -  12:30
    Systems pharmacology in drug regulation – the EMA view
    Speaker:
    12:30  -  13:00
    Where do we go from here?
    13:00  -  13:15
    Closure of the Meeting
    Speaker:
    13:15  -  14:00
    Farewell Lunch
     

    Satellite

    14:00  -  16:00
    Satellite Open Forum - Systems Pharmacology – towards a European Research Network
    The purpose of the open forum is to take the next step towards the formation of a research network. This will include discussions on the activities to be developed by the network and the membership, as well as the election of the leadership of the network, and the appointment of a steering committee.
    Open Forum announcement
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