9:00 - 10:00
Cre-lox Basics: Generating Knockout Mice
Cre-lox technology has quickly become one of the most widely used and versatile tools for genetically engineering mice for human disease modeling. Join us as we introduce you to the principles of the technology, discuss basic research applications and demonstrate how to access the world’s largest collection of Cre-lox strains.
10:00 - 11:00
Introduction to Humanized Mice for Cancer Immunotherapy
The mammalian immune system has developed surveillance mechanisms that can detect cancerous cells; however successful tumor cells have evolved strategies to evade detection. Current therapeutic strategies focus on improving cancer cell recognition and tumor elimination. Mouse models have been instrumental in the development of these therapies, including both immunocompetent and immunodeficient mice.
11:00 - 11:30
11:30 - 12:30
Predictive Cancer Models Using Patient-derived Xenograft Mice
Patient-derived xenograft (PDX) mouse models show great promise as predictive cancer models which recapitulate the heterogeneity of human cancer and are easily accessible to researchers. In this seminar, you will learn about the diversity, characterization, genetics, pathology, treatment response, and accessibility of PDX models.
University College LondonWilkins Building (Main Building),Gower Street,London WC1E 6BTUnited Kingdom
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