"Evaluation of Adult Growth Hormone Deficiency: Current and Future Perspectives"
Physiological growth hormone (GH) secretion is pulsatile, and pulsatile secretion accounts for > 85% of total daily GH secretion. Due to its pulsatile secretion, serum GH levels vary between peaks and troughs. In addition, GH secretion is influenced by factors such as nutrition, sleep patterns, and physical activity. Peripheral GH actions are primarily mediated through IGF-I synthesized in the liver. Insulin-like growth factor-I (IGF-I) has a longer half-life in the circulation than GH and is considered to provide an integrated measure of GH secretion. However, serum IGF-I levels frequently overlap in adults with GH deficiency (GHD) and normal subjects. Furthermore, serum IGF-I levels decline with normal aging, and tend to be low in obesity and in patients with non-alcoholic fatty liver disease. For these reasons, a diagnosis of adult GHD cannot be established by a single random measurement of serum GH or IGF-I level, but is dependent on the demonstration of a subnormal rise in peak serum GH level in response to one or more dynamic stimulation tests.
Kevin CJ Yuen, MD, FRCP (UK)
Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Medicine, Oregon Health and Science University, Portland, OR 97239-3098, firstname.lastname@example.org
Lindsay E. Chong, MD
Division of Endocrinology, Clinical Fellowship, Oregon Health and Science University, Portland, OR 97239, email@example.com
Sharon A. Rhoads, RN, BSN
Division of Endocrinology, Endocrine Testing Unit Coordinator, Oregon Health and Science University, Portland, OR 97239, firstname.lastname@example.org
This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education. The University of Mississippi School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to sponsor continuing medical education for physicians.
Intended Audience This continuing medical education program is intended for physicians, nurse practitioners, and other interested healthcare professionals.
Completion time, Assessment, and Evaluation It is estimated that it will require 2 hour to review the text material in this continuing medical education program and answer the self-assessment questions. After completing the program, answer post test questions and evaluation questions through CVENT. A minimum of 70% of the questions must be answered correctly to receive credit. Upon successful completion of the post test and evaluation, you will be emailed a certificate of completion within 7 days. Copyright Copyright © 2013 University of Mississippi School of Medicine. All rights reserved. No part of this report may be used or reproduced in any manner whatsoever without written permission except in the case of brief quotations embedded in articles or reviews. Contact Us Inquires regarding the content of this CME program should be addressed to: Ashley Givens, e-Learning Coordinator- email@example.com
Ashley Givens, Continuing Education, University of Mississippi Medical Center
Cvent Online Event Registration Software | Copyright © 2000-2017 Cvent, Inc. All rights reserved.