ENDOTEXT Series: Staying Current in Endocrinology " Hashimoto's Thyroiditis" Hashimoto’s thyroiditis is characterized clinically as a commonly occurring, painless, diffuse enlargement of the thyroid gland occurring predominantly in middle-aged women. The patients are often euthyroid, but hypothyroidism may develop. The thyroid parenchyma is diffusely replaced by a lymphocytic infiltrate and fibrotic reaction; frequently, lymphoid germinal follicles are visible. Attention has been focused on this process because of the demonstration of autoimmune phenomena in most patients. Persons with Hashimoto’s thyroiditis have serum antibodies reacting with TG, TPO, and against an unidentified protein present in colloid.
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