Join Karen L. Reckamp, MD and Carrie Christiansen, RN, MSN, CFNP from City of Hope Comprehensive Cancer Center as they present their expertise on a range of cases pertaining to lung cancer.
The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Non-Small Cell Lung Cancer (NSCLC) were recently revised to include recommendations regarding subsequent therapy for patients with metastatic NSCLC based on data about the efficacy of immune checkpoint inhibitors, such as nivolumab and pembrolizumab. The phrase subsequent therapy was recently substituted for the term second-line or beyond systemic therapy in the NCCN Guidelines® for Non-Small Cell Lung Cancer because the line of therapy may vary depending on previous treatment. Immune checkpoint inhibitors are now recommended as preferred agents for subsequent therapy for patients with metastatic NSCLC, because they improve overall survival, have a longer duration of response, and have fewer side effects when compared with cytotoxic chemotherapy such as docetaxel. The NCCN Panel recommends nivolumab (category 1) and pembrolizumab (category 1) as subsequent therapy for patients with metastatic NSCLC based on data from clinical trials and FDA approvals. Nivolumab and pembrolizumab are IgG4 monoclonal antibodies that inhibit the programmed cell death protein—1 (PD-1) pathway, which improves antitumor immunity; PD-1 receptors are expressed on activated cytotoxic T-cells. T-cell activation is inhibited when ligands from tumor cells, such as programmed death--ligand 1 (PD-L1), activate PD-1 pathways; thus, tumor cells are hidden to the immune system.
The NCCN Guidelines® for Non-Small Cell Lung Cancer are updated to reflect the current state of clinical practice for the management of non-small cell lung cancer, based on recent scientific publications and the availability of new treatment options. Some of the recent updates include the addition of atezolizumab and expanded indications for pembrolizumab.
NCCN is offering a series of twelve multidisciplinary case-based webinars on a variety of topics, bladder cancer, breast cancer, colorectal cancer, kidney cancer, lung cancer, melanoma, multiple myeloma, myelofibrosis, ovarian cancer, peripheral T-cell lymphomas, prostate cancer and sarcoma. Each webinar will be facilitated by at least two faculty members. A different topic will be presented each month for twelve months (June 2016 until June 2017). The goal of this Series is to ensure that members of a multidisciplinary team, including physicians, nurses, pharmacists and other relevant healthcare professionals, have the knowledge and skills necessary to apply the standards of care to their practice and healthcare setting for patients with various cancer types.
The NCCN Clinical Practice Guidelines in Oncology® (NCCN Guidelines®) are a set of step-by step evidence-based, consensus-driven recommendations that ensure that patients receive preventive, diagnostic treatment, and care that is most likely to lead to optimal outcomes. The NCCN recommendations are applicable to about 95% of patients. Clinicians need to consider the current clinical status of the patient, including general health, disease specifics, concomitant conditions, current and previous therapies, and the patients how to best apply appropriate standard of care including identifying circumstances where appropriate management requires adapting the NCCN Guidelines to the needs of the individual. This activity series will discuss the specific recommendations in the NCCN Guidelines as well as unique patient circumstances that impact how the NCCN Guidelines might be best applied.
Monday, February 27, 2017 1:00 PM - 2:00 PMEastern Time
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