Join Gregory Daniels, MD, PhD and Brian Hinds, MD from the University of California, San Diego as they present their expertise on a range of cases pertaining to melanoma.
It was estimated that in 2015, 73,870 patients in the United States would be diagnosed with melanoma and about 9940 would die from the disease. The incidence of melanoma continues to increase dramatically, at an overall rate of 33% for men and 23% women from 2002 to 2006. On average, an individual loses 20.4 years of potential life as a result of melanoma mortality compared to 16.6 years for all malignancies. The landscape of treatment options for advanced melanoma is both particularly complex and rapidly shifting. Recently published results from large randomized trials in advanced melanoma support FDA approvals and changes in the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Melanoma that significantly increase the number of recommended treatment options for phase III and phase IV disease. New recommended treatment options include (1) biochemotherapy and high-dose ipilimumab for select patients with Stage III disease rendered free of disease by surgery; (2) intralesional injection with talimogene laherparepvec for primary treatment of stage III in-transit disease and select lesions in patients with stage IV disease; and (3) two combination therapy regimens for metastatic or unresectable disease: nivolumab/ipilimumab and vemurafenib/cobimetinib (for BRAF mutated melanoma). In addition to these newly added drug-based therapy options, the NCCN Guidelines® for Melanoma have also retained many other options for patients with advanced disease, including treatment in a clinical trial, pharmaceutical agents applied locally, regionally, or systemically, and other treatment modalities (e.g., surgery, radiation therapy, and laser ablation). The recommended treatment options for advanced melanoma are diverse in mechanism of action, method of administration, safety profiles, and patterns of response.
NCCN is offering a series of twelve multidisciplinary case-based webinars on a variety of topics, bladder cancer, breast cancer, colorectal cancer, kidney cancer, lung cancer, melanoma, multiple myeloma, myelofibrosis, ovarian cancer, peripheral T-cell lymphomas, prostate cancer and sarcoma. Each webinar will be facilitated by at least two faculty members. A different topic will be presented each month for twelve months (June 2016 until June 2017). The goal of this Series is to ensure that members of a multidisciplinary team, including physicians, nurses, pharmacists and other relevant healthcare professionals, have the knowledge and skills necessary to apply the standards of care to their practice and healthcare setting for patients with various cancer types.
The NCCN Clinical Practice Guidelines in Oncology® (NCCN Guidelines®) are a set of step-by step evidence-based, consensus-driven recommendations that ensure that patients receive preventive, diagnostic treatment, and care that is most likely to lead to optimal outcomes. The NCCN recommendations are applicable to about 95% of patients. Clinicians need to consider the current clinical status of the patient, including general health, disease specifics, concomitant conditions, current and previous therapies, and the patients how to best apply appropriate standard of care including identifying circumstances where appropriate management requires adapting the NCCN Guidelines to the needs of the individual. This activity series will discuss the specific recommendations in the NCCN Guidelines as well as unique patient circumstances that impact how the NCCN Guidelines might be best applied.
Thursday, November 10, 2016 1:30 PM - 2:30 PMEastern Time
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