Agenda

SUNDAY, AUGUST 6
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5:00-8:00pm    Welcome Reception (Student Life Center)

MONDAY, AUGUST 7
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Origin of CEST Contrast

 8:00amOpening Remarks
Seth Smith, Vanderbilt University Medical Center, Nashville, TN
 8:15amCEST, MTC, and NOE Basics and the In Vivo Z-Spectrum
Peter van Zijl, Johns Hopkins University, Baltimore, MD
 8:40amCEST Specificity and the Role of Pulsed Methods
Daniel Gochberg, Vanderbilt University Medical Center, Nashville, TN
 9:05amImaging Glucose Uptake and Metabolism with CEST and CESL MRI
Seon-Gi Kim, Sungkyunkwan University, Suwon, Korea


9:30-10:10am Poster Power Pitch
 Session #1

 9:30amHighly sensitive pH mapping during ischemia using Total Fast-exchanging Protons (TFP) imaging
Jiadi Xu, Johns Hopkins University, Baltimore, MD
 9:34amAccelerating CEST Imaging with Generalized K-SVD
Huajun She, UT Southwestern Medical Center, Dallas, TX
 9:38amFaster APT imaging with variably-accelerated sensitivity encoding (vSENSE)
Yi Zhang, Johns Hopkins University, Baltimore, MD
 9:42amDetection of dynamic substrate binding using MRI
Nirbhay Yadav, Johns Hopkins University, Baltimore, MD
 9:46am
Optimized adiabatic spin-lock pulses for robust dynamic glucose enhanced MRI at 3T and 9.4T
Kai Herz, Max-Planck-Institute for biological cybernetics, Tuebingen, Germany
 9:50am
Visualization of Amide Proton Transfer (APT) with Chemical Exchange Rotation Transfer (CERT) on Human White Matter at 3T
Eugene Lin, Vanderbilt University Medical Center, Nashville, TN
 9:54am
Contribution of Chemical Exchange to R1ρ Dispersion
Ping Wang, Vanderbilt University Medical Center, Nashville, TN
 9:58am
CEST MRI: A Phantom Investigation into the Biosynthesis Pathway of Serotonin
Ryan Oglesby, Sunnybrook Research Institute, Toronto, Canada
 10:02am
A machine learning approach to measure pH using CEST MRI
Marty Pagel, MD Anderson Cancer Center, Houston, TX
 10:06am
GlucoCEST Imaging with On-Resonance Variable Delay Multiple Pulse (onVDMP) MRI
Xiang Xu, Johns Hopkins University, Baltimore, MD


10:10-10:45am         Coffee Break 

 

Method Development

 10:45amCEST Fingerprinting
Zhengwei Zhou, University of California, Los Angeles, CA
 11:10amVDMP/FLEX Basics and Applications
Nirbhay Yadav, Johns Hopkins University, Baltimore, MD
 11:35amHow Much Amide is There in the Brain? Implication for CEST Signals from Mobile Proteins
Tao Jin, University of Pittsburgh, Pittsburgh, PA
 12:00pmRatiometric CEST for Quantitative pH Measurement Using Temperature Calibration from BIRDS
John Walsh, Yale University, New Haven, CT

 

12:25-1:30pm      LUNCH (boxed lunches)

1:30-2:30pm Poster Power Pitch Session #2

 1:30pmDynamic Glucose Enhance Imaging at 3T
Xiang Xu, Johns Hopkins University, Baltimore, MD
 1:34pmMRI-CEST pH imaging: a new tool for assessing in vivo the early response and onset of resistance to dichloroacetate in a murine breast cancer model
Dario Longo, University of Torino, Torino, IT
 1:38pmSeparating NOEs and Semisolid MT in Quantitative Imaging of Hyperacute Stroke
Yunus Msayib, University of Oxford, Oxford, UK
 1:42pm
Can Solute Exchange Rate Be Decoupled from Concentration with Measurements over a Range of Concentrations?
Wilfred Lam, Sunnybrook Research Institute, Toronto, Canada
 1:46pm
Quantification of hydroxyl exchange of D-Glucose at physiological conditions for optimization of glucoCEST MRI
Moritz Zaiss, Max-Planck-Institute for biological cybernetics, Tuebingen, Germany
 1:50pm
How many frequencies? Reducing acquisition time for clinical application of  model-based analysis of CEST data
Paula Croal, University of Oxford, Oxford, UK
 1:54pm
CEST imaging using a concentric rings trajectory
Neil Wilson, University of Pennsylvania, Philadelphia, PA
 1:58pm
Is Normal Appearing White Matter of Glioblastoma Multiforme (GBM) Patients Really Normal?
Hatef Mehrabian, University of California, San Francisco, CA
 2:02pm
3-O-Methyl-D-Glucose uptake and accumulation in brain tumor cells through CEST MRI
Akansha Sehgal, Johns Hopkins School of Medicine, Baltimore, MD
 2:06pm
Towards simultaneous imaging of the distribution of drug-containing nanoparticles and their therapeutic effect on the tumor microenvironment
Samuel Maritim, Yale University, New Haven, CT
 2:10pm
A pH-controlled muscle model for CEST
Elizabeth Louie, Vanderbilt University Medical Center, Nashville, TN
 2:14pm
Reproducibility of Creatine CEST (CrCEST) in vivo in healthy human muscle at 3T
Catherine DeBrosse, University of Pennsylvania, Philadelphia, PA
 2:18pm
Clinical Translation of Tumor Acidosis Measurements with acidoCEST MRI
Marty Pagel, MD Anderson Cancer Center, Houston, TX
 2:22pm
Assessment of a clinically feasible Bayesian fitting algorithm using a simplified description of Chemical Exchange Saturation Transfer (CEST) Imaging: a simulated study
Aaron Kujawa, University College London, London, UK


2:30-3:45pm         Poster Session #1 (Abstracts in Pitch Sessions 1 and 2)

 

CEST Quantification

 3:45pmBasics of AREX and Inverse Correction Methods
Moritz Zaiss, Max-Planck Institute for Biological Cybernetics, Tuebingen, Germany
 4:10pmRapid Quantification: Omega Plots and Spillover
Phillip Zhe Sun, Harvard Medical School, Boston, MA
 4:35pmStatistical Quantification of the CEST Effect
Michael Chappell, University of Oxford, Oxford, UK
 5:00pmCEST in the presence of MT
Greg Stanisz, Sunnybrook Research Institute, Toronto, Canada


6:00pm         Reception and Dinner for Invited Speakers and Planning Committee
(Buses will be waiting for transport)

 


TUESDAY, AUGUST 8
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Contrast Agents for CEST

 8:00amResponsive ParaCEST Agents - Overview, Design, and Possible Limitations for In Vivo Use
Dean Sherry, University of Texas Southwestern, Dallas, TX
 8:25amDiaCEST Contrast Agents and Theranostics
Guanshu Liu, Johns Hopkins University, Baltimore, MD
 8:50amLipo-CEST and Cell-CEST
Silvio Aime, University of Torino, Torino, IT
 9:15amCatalyCEST
Marty Pagel, MD Anderson Cancer Center, Houston, TX

 

9:40-10:20 Poster Power Pitch Session #3

 9:40amMRI-CEST iodinated contrast media as potential alternatives to conventional Gd-based agents for contrast-enhanced tumor imaging
Dario Longo, University of Torino, Torino, IT
 9:44amEnzyme responsive LipoCEST agents
Silvio Aime, University of Torino, Torino, IT
 9:48amCEST pH Imaging Methods using Salicylic Acid Derivatives
KowsalyaDevi Pavuluri, Johns Hopkins University School of Medicine, Baltimore, MD
 9:52amHydrazo-CEST Probes Towards Imaging Aldehydes In Living Subjects
Adam Shuhendler, University of Ottawa, Ontario, Canada
 9:56am
CEST MRI detection of TAT peptide and TAT-based nanoparticles
Jia Zhang, Johns Hopkins University School of Medicine, Baltimore, MD
 10:00am
Plasma volume expanders as potential blood pool contrast agents for MRI-CEST applications
Dario Longo, University of Torino, Torino, IT
 10:04am
Imaging extracellular lactate in vivo using CEST and a paramagnetic shift reagent
Andre Martins, UT Dallas, Richardson, TX
 10:08am
Intracellular Assembly of Theranostic Nanoparticles for CEST MR Imaging and Cancer Therapy
Yue Yuan, Johns Hopkins School of Medicine, Baltimore, MD
 10:12am
Use of Pharmacologic CEST to Optimize Glioblastoma Acidification
Robert Bartha, Western University, Ontario, Canada
 10:16am
Exploring iodinated contrast media as chemical-exchange spin-lock (CESL) agents for tumor imaging
Dario Longo, University of Torino, Torino, IT


10:20-10:50am        Coffee Break

 

Musculoskeletal and Beyond

 10:50amCardiac CEST: Challenges, Applications, and Opportunities
Moriel Vandsburger, University of California, Berkeley, CA
 11:15amPeripheral CEST in Patients with Lymphatic Dysfunction
Rachelle Crescenzi, Vanderbilt University Medical Center, Nashville, TN
 11:40amMagnetization Transfer Ratio (NOE_MTR) as a Biomarker of Hip Osteoarthritis
Hatef Mehrabian, University of California, San Francisco, CA
 12:05pmsnapCEST for High-Resolution 3D GagCEST in the Knee Joint at 7T
Johannes Windschuh, New York University, Langone Medical Center, New York, NY


12:30-1:30pm        LUNCH (boxed lunches)

1:30-2:30pm Poster Power Pitch Session #4

 1:30pmIdentification of the specific contribution of the neuronal compartment to the gluCEST contrast
Julien Flament, Commissariat à l'Energie Atomique / INSERM, Fontenay-aux-Roses, France
 1:34pmDifferentiating Radiation Necrosis from Tumor Progression in Human Brain Metastases
Hatef Mehrabian, University of California, San Francisco, CA
 1:38pmDistinguishing Isocitrate Dehydrogenase Genotype in Glioma Non-invasively Using Amide Proton Transfer-Weighted (APTw) Imaging
Shanshan Jiang, Johns Hopkins University School of Medicine, Baltimore, MD
 1:42pmDetection of the accumulation of mannitol in rat brains using CEST MRI
Jing Liu, Johns Hopkins University School of Medicine, Baltimore, MD
 1:46pm
Using CEST MRI to Differentiate Radioresistant and Non-Radioresistant Prostate Cancer In Vivo
Jonathan Klein, University of Toronto, Ontario, Canada
 1:50pm
Cardiac chemical exchange saturation transfer MRI reveals reduced myocardial creatine in obese individuals despite preserved ejection fraction and global longitudinal shortening
Wissam AlGhuraibawi, University of California, Berkeley, CA
 1:54pm
Evaluation of T1p time in the quadriceps muscle after an Anterior Cruciate Ligament Reconstruction: Relationship to muscle strength and injury recovery
Brian Noehren, University of Kentucky, Lexington, KY
 1:58pm
Imaging brown adipose tissue mass and activity with Z-spectral imaging
Kejia Cai, University of Illinois at Chicago, Chicago, IL
 2:02pm
Probing Pathological Substrates of Gray Matter Damage in Multiple Sclerosis with CEST
Kristin O'Grady, Vanderbilt University Medical Center, Nashville, TN
 2:06pm
Monitoring Glutamate in Experimental Autoimmune Encephalomyelitis using VDMP-CEST MRI
Aline Thomas, Johns Hopkins University School of Medicine, Baltimore, MD
 2:10pm
Assessing vascularity, cellularity, and acidity of gliomas: Implications for CEST imaging
Fahmeed Hyder, Yale University, New Haven, CT
 2:14pm
Temozolomide Treatment Normalizes Intratumoral Extracellular pH in Gliomas as Measured by BIRDS
John Walsh, Yale University, New Haven, CT
 2:18pm
Dissecting the heterogeneous microenvironment of brain tumors: Implications for CEST imaging
Fahmeed Hyder, Yale University, New Haven, CT
 2:22pm
About the complementarity of gluCEST and 1H-MRS for the study of neurodegenerative diseases
Julien Flament, Commissariat à l'Energie Atomique / INSERM, Fontenay-aux-Roses, France
 2:26pm
Longitudinal Evaluation GBM response to therapy with quantitative MT and CEST
Hatef Mehrabian, University of California, San Francisco, CA


2:30-3:45pm        Poster Session #2 (Abstracts in Pitch Sessions 3 and 4)

 

CEST in Neurology

 3:45pmCEST Beyond APT: Emerging Applications in Neuroimaging
Ravi Reddy, University of Pennsylvania, Philadelphia, PA
 4:10pm
APT in Stroke/Ischemia
Hye-Young Heo, Johns Hopkins University, Baltimore, MD
 4:35pmIn Vivo GluCEST MRI: Reproducibility, Background Contribution, and Source of Glutamate Changes in the MPTP Model of Parkinson’s Disease
Puneet Bagga, University of Pennsylvania, Philadelphia, PA
 5:00pmChemical Exchange Saturation Transfer and Magnetic Resonance Spectroscopy for the Evaluation of Brain Metabolic Response to Probiotic Diet in Animal Model of Depressive Disorders
Anna Orzylowska, Medical University of Lublin, Lublin, Poland

 

5:30pm         Group Picture
 


WEDNESDAY, AUGUST 9
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CEST in Oncology

 8:00amGlucosamine/GlucoCEST
Gil Navon, Tel Aviv University, Tel Aviv, Israel
 8:25amTowards an Early Detection of Prostate Cancer Using Zinc-Sensitive iCEST MRI
Yue Yuan, Johns Hopkins School of Medicine, Baltimore, MD
 8:50amCEST for Human Breast Lesion Characterization at 3T: A Preliminary Study
Shu Zhang, University of Texas Southwestern Medical Center, Dallas, TX
 9:15amNOE Imaging of Glioblastoma in the Course of Radiotherapy at 7T
Jan-Eric Meissner, German Cancer Research Center (DKFZ), Heidelberg, Germany

 

9:40-10:10am     Coffee Break 

 

Rapid Methods and Alternative Contrasts

 10:10am Beyond CEST: Alternative Ways to Detect Chemical Exchange
Elena Vinogradov, University of Texas Southwestern, Dallas, TX
 10:35amrNOE-CEST Signal at -1.6 ppm
Zhongliang Zu, Vanderbilt University Medical Center
 11:00amEndogenous Contrast MRI of ROS
Kejia Cai, University of Illinois, Chicago, IL
 11:25amProspective Baseline Enhancement (PROBE) in Z-Spectra by Variable Saturation Power - Probing Lactate via NOE at 3T and 7T (in vitro)
Tobias Lenich, Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, Germany


11:50-12:30pm Standardization / Round Table Discussion

12:30-12:45pm  Closing Comments and Adjourn (Seth Smith)

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