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Strategies for an HIV Cure 2018
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Meeting Agenda & Location

Agenda

Download: Agenda (pdf)

Wednesday October 10th

 7:30 am - Registration Opens
 8:30 am - Welcome, Announcements and Keynote Speaker Introduction
Karl Salzwedel, NIAID
 8:40 am - Keynote I: Anthony Fauci, NIAID


Martin Delaney Collaboratory Research Highlights

 9:00 am - I4C: Combined Immunological Approaches to Cure HIV-1
Dan Barouch, Beth Israel Deaconess Medical Center
 9:20 am - BEAT-HIV: Delaney Collaboratory to Cure HIV-1 Infection by Combination Immunotherapy
Luis Montaner, Wistar Institute
 9:40 am - BELIEVE: Bench to Bed Enhanced Lymphocyte Infusions to Engineer Viral Eradication
Douglas Nixon, Weill Cornell Medicine
10:00 am - CARE: Collaboratory of AIDS Researchers for Eradication
David Margolis, University of North Carolina, Chapel Hill
10:20 am - defeatHIV: Delaney Cell and Genome Engineering Initiative
Keith Jerome, Fred Hutchinson Cancer Research Center
10:40 am - DARE: Delaney AIDS Research Enterprise to Cure HIV
Steven Deeks, University of California, San Francisco

11:00 am - Break (Poster Viewing and Networking)


Session I: Finding the Reservoir *

Chairs: Janice Clements, Johns Hopkins University and Elizabeth Connick, University of Arizona

11:25 am - HIV-1 Modulates Host Gene Expression at the Integration Site
Ya-Chi Ho, Yale School of Medicine
11:40 am - Characterizing Host Pathways that Regulate Latency in a Primary Cell Model
Edward Browne, University of North Carolina, Chapel Hill
11:55 am - Characterization of Latent and Active HIV Reservoirs in Blood and Tissues
Nicolas Chomont, Université de Montréal
12:10 pm - Novel In Situ Approaches to Characterize Viral Reservoirs
Jacob Estes, Oregon Health & Science University
12:25 pm - Developing Imaging Approaches to Define the Early Mucosal SIV Reservoir
Thomas Hope, Northwestern University
12:40 pm - Panel Discussion

 1:00 pm - Lunch (On Your Own)

 2:00 pm - Poster Session  


Session II: Quantifying the Reservoir *

Chairs: Nancie Archin, University of North Carolina, Chapel Hill and John Mellors, University of Pittsburgh
 3:15 pm - Genomic Landscapes of HIV, SIV, and SHIV: Relevance to Measuring the Latent Reservoir in Cure Studies
Robert Siliciano, Johns Hopkins University
 3:30 pm - Insights into HIV Reservoir Assay Performance from the RAVEN Program
Michael Busch, Blood Systems Research Institute
 3:45 pm - Determining Early HIV Decay Dynamics upon Treatment Initiation
Elizabeth Anderson, HIV Dynamics and Replication Program, NCI
 4:00 pm - A Phylogenetic Approach to Estimate Integration Dates of Individual Latent HIV Sequences Within-Host
Zabrina Brumme, Simon Fraser University
 4:15 pm - Using Reactivation Rates to Quantify the Viral Reservoir
Brandon Keele, AIDS and Cancer Virus Program, NCI
 4:30 pm - Panel Discussion

 5:00 pm - Adjourn Day 1

 

Thursday October 11th

 8:25 AM - Announcements and Keynote Speaker Introduction
Lillian Kuo, NIAID
 8:30 AM - Keynote II: CD4-mimetic Compounds: Sensitization of HIV-1 to Sub-dominant Antibody Responses
Joseph Sodroski, Dana-Farber Cancer Institute


Session III: Overcoming Latency *

Chairs: Richard D’Aquila, Northwestern University and Vicente Planelles, University of Utah
 9:00 am - Dual TLR2 and TLR7 Agonists as HIV Latency-reversing Agents
Amanda Macedo, George Washington University
 9:15 am - BCL-2 Antagonism Enables CTL-Mediated Elimination of Ex Vivo CD4 Reservoirs
R. Brad Jones, Weill Cornell Medicine
 9:30 am - Systemic In Vivo Induction of the Latent HIV Reservoir via the Non-canonical NF-kB Signaling Pathway
J. Victor Garcia, University of North Carolina, Chapel Hill
 9:45 am - Latency Reversal in Nonhuman Primates
Ann Chahroudi, Emory University
10:00 am - Combination Therapies with TLR7 Agonists
Devi SenGupta, Gilead Sciences
10:15 am - Panel Discussion

10:45 am - Break (Poster Viewing and Networking)


Session IV: Killing Reservoir Cells *

Chairs: Sharon Riddler, University of Pittsburgh and Lydie Trautmann, Military HIV Research Program
11:05 am - Towards HIV-1 Remission with AAV-expressed eCD4-Ig
Matthew Gardner, Scripps Research Institute
11:20 am - How Many mAbs to Target the Latent Reservoir?
Guido Ferrari, Duke University
11:35 am - Novel Humanized Mouse Model to Investigate In Vivo Activation and bNAb-mediated Depletion
of Patient-Derived HIV Latent Reservoirs
Harris Goldstein, Albert Einstein College of Medicine
11:50 am - Trafficking of Stem Cell-Derived CAR T-Cells to B-Cell Follicles in SHIV-Infected Nonhuman Primates
Christopher Peterson, Fred Hutchinson Cancer Research Center
12:05 pm - Why HIV-specific T cells Engineered with CARs Work Better than Those Engineered with TCRs
James Riley, University of Pennsylvania
12:20 pm - HIV-Resistant CAR T Cells in SHIV-infected Non-human Primates
Thor Wagner, Seattle Children's Hospital
12:35 pm - Panel Discussion

 1:00 pm - Lunch (On Your Own)

 2:00 pm - Poster Session


Session V: Immunomodulation and Immunologic Control of Viremia *

Chairs: Jonathan Karn, Case Western Reserve University and Jeffrey Lifson, Frederick National Laboratory
 3:00 pm - Understanding CD8+ T Cell Function During Antiretroviral Therapy
Afam Okoye, Oregon Health & Science University
 3:15 pm - Generating Functional HIV-specific CD8+ T Cells
Rachel Rutishauser, University of California, San Francisco
 3:30 pm - Myeloid-derived Suppressor Cells Expand During Analytic treatment Interruption and Decrease
Anti-viral T cell Responses in Combinatorial HIV Curative Therapy
Sandra Dross, University of Washington
 3:45 pm - Combination Immunotherapy to Induce Viral Remission
James Whitney, Beth Israel Deaconess Medical Center
 4:00 pm - Neutralizing Antibody-Based HIV Cure Strategies
Dan Barouch, Beth Israel Deaconess Medical Center
 4:15 pm - Effects of Broadly Neutralizing Antibody Combinations in HIV-1 Infection
Marina Caskey, Rockefeller University
 4:30 pm - Panel Discussion

 5:00 pm - Adjourn Day 2

Friday October 12th

 8:25 AM - Announcements and Keynote Speaker Introduction
Roger Miller, NIAID
 8:30 AM - Keynote III: Silencing the HIV-1 Reservoir
Susana Valente, Scripps Research Institute


Session VI: Clinical Trials and Community Engagement *

Chairs: Adriana Andrade, NIAID and Joseph Eron, University of North Carolina, Chapel Hill
Panelists: Richard Jeffreys, Treatment Action Group and A. Toni Young, Community Education Group
 9:00 am - Meeting Report: Framework for Initiating Pediatric Studies of HIV Cure Interventions
Deborah Persaud, Johns Hopkins University
 9:15 am - Analytical Treatment Interruption in HIV Cure Trials – Report of a Consensus Workshop
Boris Juelg, Ragon Institute
 9:30 am - Acceptability of Target Product Profiles for an HIV Cure Regimen According to Adults Living with HIV
in the U.S.
Karine Dubé, University of North Carolina, Chapel Hill
 9:45 am - The Last Gift: Performing HIV Cure Research at the End of Life
Sara Gianella Weibel, University of California, San Diego
10:00 am - Panel Discussion

10:30 am - Break (Poster Viewing and Networking)


Session VII: Viral Rebound and Post Treatment Control *

Chairs: Rajesh Gandhi, Massachusetts General Hospital and Nelson Michael, Military HIV Research Program
10:50 am - Lessons Learned from Brief ATI Trials in the RV254 Cohort to Inform Future ATI Designs
Jintanat Ananworanich, Military HIV Research Program
11:05 am - Preliminary Testing of a bNAb Susceptibility Screening Assay
Katherine Bar, University of Pennsylvania
11:20 am - The Majority of the Replication-competent Virus in the Latent Reservoir Originates from Viruses Replicating
Near the Time of ART Initiation
Sarah Joseph, University of North Carolina, Chapel Hill
11:35 am - Impact of Analytical Treatment Interruption on HIV Dynamics
Tae-Wook Chun, NIAID
11:50 am - Understanding Post-Treatment HIV Control
Jonathan Li, Brigham and Women's Hospital
12:05 pm - Panel Discussion

12:30 pm - Closing Remarks, Adjourn


*Sessions will be comprised of short 12-minute talks in a total 15-minute slot per speaker, then followed by a 20 to 30-minute panel discussion with all speakers

Location


Natcher Conference Center
45 Center Drive
NIH Main Campus
Bethesda, Maryland 20892 USA
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