NIH-NIAID-Conferences-20558a

U.S.-Japan Cooperative Medical Sciences Program (USJCMSP) 21st International Conference on Emerging Infectious Diseases in the Pacific Rim

Mycobacteria Panel Meeting

 28 February - 1 March 2019

Hanoi, Vietnam

 

Day 1: Host Response and Pathogenesis                                                                                                                   

8:30am

Welcome & Opening Remarks

Yasuhiko Suzuki & Steven Reed

Mycobacterial Panel Chairs

Japan & USA

Session 1: Pathology and Immune Responses

Session Chairs: Sabine Ehrt (USA), Shokichi Matsumoto(Japan)

9:00am

Heterogeneity of granulomas in tuberculosis provides opportunities to identify protective mechanisms

JoAnne Flynn

USA

9:20am

Effects of mycobacteria derived Zmp1 on innate and T-cell immune Responses

Masayuki Umemura

Japan

9:40am

Chronic Immune Activation Rather than Mere CD4+ T cell Depletion is Associated with Reactivation of Latent TB

Deepak Kaushal

USA

10:00am

Suppression of the Host Immune Responses by Mycobacteria through Inhibitory Receptors

Naoya Nishimura

Japan

10:20am

BREAK

 

 

10:40am

Recognition of Mycobacterial Glycolipids via Host

Immune Receptors

Sho Yamasaki

Japan

11:00am

The Immune Activation Induced by a Mycobacterial Hydrophilic Component

Shota Torigoe

Japan

11:20am

Low Serum Estradiol Levels in Postmenopausal Women with Mycobacterium Avium Complex Pulmonary Disease

Yoshifumi Uwamino

Japan

11:40am

Evaluation of Anti-Glycopeptidelipid Core Antigen

ELISA for Non-Tuberculosis Mycobacterium Diseases in Asian Countries

Manabu Ato

Japan

NOON

Lunch/Poster Session

 

 

Session 2: Bacterial Adaptation

Session Chairs: Yasuhiko Suzuki (Japan), Steven Reed (USA)

1:40pm

Genome wide assessment of Mycobacterium

tuberculosis conditionally essential metabolic pathways

Yusuke Minato

USA

2:00pm

Long term survival and organizations of the genome

by the intrinsically disordered histone-like protein in mycobacteria and its application to the diagnosis of asymptomatic tuberculosis

Sohkichi

Matsumoto

Japan

2:20pm

The peptidoglycan amidase Ami1 is required for

normal cell division in the absence of the endopeptidase RipA

Sabine Ehrt

USA


 

2:40pm

Molecular Surveillance of Ceftazidime (CAZ)

Resistance in Melioidosis*

Apichai Tuanyok

USA

3:00pm

Making and breaking proteins in mycobacteria - the

great LepA forward

Eric Rubin

USA

3:20pm

BREAK

 

 

Session 3: New Insights into Leprosy

Session Chairs: Tetsu Mukai (Japan), Eric Rubin (USA)

3:40pm

Leprosy diagnostic methods: Detection of paucibacillary patients

Yumi Maeda

Japan

4:00pm

Genetic diversity, drug resistance and distribution of M. leprae from 62 clinical isolates from Brazil

John Spencer

USA

4:20pm

Detection of Mycobacterium leprae DNA in nasal swabs by dried loop-mediated isothermal amplification

Tetsu Mukai

Japan

4:40pm

WQ-3810 shows strong inhibitory activity against quinolone-resistant DNA gyrases of Mycobacterium leprae

Jong-Hoon Park

 

 

 

Japan

5:00pm

Adjourn

 

 

 

*Awardee of U.S.-Japan Cooperative Medical Sciences Program Collaborative Awards

 

 

Day 2: Treatment and Prevention

8:45am

Opening Remarks

Session 4:  TB Prevention, Drug Tolerance and Resistance Session Chairs: John Spencer (USA), Masayuki Umemura (Japan)

9:00am

Clinical Development of a Next Generation Tuberculosis vaccine

Steven Reed

USA

9:20am

Effect of population-wide screening on the prevalence of TB: a cluster randomised trial in Vietnam

 

Dr Nguyen Thu Anh

 

Vietnam

9:40am

Iron transport and electrochemical gradients modulate clofazimine lethality

 

Martin Voskuil

 

USA

10:00am

Molecular mechanisms of M.

tuberculosis mutagenesis and antibiotic resistance

 

Michael Glickman

 

USA

10:20am

Bugs and Drugs: Finding New Ways to Combat TB

 

David Sherman

 

USA

10:40am

BREAK

Session 5: Drug Tolerance and Resistance

Session Chairs: Manabu Ato (Japan), Nguyen Thu Anh (Vietnam)

11:20am

Genome-scale CRISPR interference (CRISPRi) to advance TB drug discovery

Jeremy Rock

USA

11:40am

Fitness cost and compensatory mechanism in quinolone resistant Mycobacterium tuberculosis

Yuki Ouchi

Japan

Noon

Closing Remarks

TBD & Dr. Steven Reed

Mycobacterial

Panel Chairs

USA & Japan

12:20pm

Lunch

 

** Note: Talks are 15 minutes + 5 minutes of discussion

 

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