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21c Museum Hotel | St. Louis

1528 Locust Street, St. Louis, MO, USA, 63103
Venue image

About us

21c Museum Hotels reimagines a historic St. Louis fixture: the 10-story, Renaissance Revival-style YMCA building. Located in the heart of downtown St. Louis, and a short walk from the City Museum and CITYPARK stadium, 21c Museum Hotel St. Louis includes a 173-room boutique hotel, contemporary art museum, Idol Wolf restaurant, Good Press café, and Locust Street Athletic and Swim Club, a full-service wellness center. With more than 14,000 square feet of exhibition and meeting & event space seamlessly integrated into all areas of the property, there are opportunities to discover contemporary art around every corner.

Venue Details

ChainAccor
Brand21C Museum Hotel
Built2023
Renovated-
Total meeting space14,000 sq. ft.
Guest Rooms173
Venue typeBoutique hotel

Industry Ratings

AAA
Forbes Travel Guide

Awards

Industry awards
Sleeper AHEAD Top 100 Hotels in World 2025 Top 25 Hotels - Historic Hotels of America 4 Green Keys Rating - Green Key Global Conde Nast: "The gallery spaces are certainly the star of the show here, but it’s unsurprising that an elevated sensibility has seeped into each of the property’s 173 guest rooms." Hotel's Above Par: "If you’re the kind of traveler who loves a hotel that doubles as an Instagrammable art moment and a sanctuary of design-forward, luxe creature comforts, let us introduce you to your new hotel crush: 21c Museum Hotel St Louis."

Amenities

Room features and guest services
  • Calls (local)
  • Internet access
  • Luggage storage
  • Room service
  • View (urban)
  • Voicemail box
Facilities
  • Onsite catering
  • Onsite gift shop
  • Onsite restaurant
  • Onsite security
  • Pet friendly
  • Space (outdoor)
  • Space (private)
  • Space (semi-private)
  • Wheelchair accessible

Need dates

Priority windows that venues prefer for hosting events

Dec 9, 2025 - Dec 11, 2025
Dec 14, 2025 - Dec 18, 2025
Dec 21, 2025 - Dec 25, 2025
Dec 28, 2025 - Dec 31, 2025
Jan 11, 2026 - Jan 16, 2026
Jan 18, 2026 - Jan 22, 2026
Jan 25, 2026 - Jan 29, 2026
Feb 1, 2026 - Feb 5, 2026
Feb 15, 2026 - Feb 19, 2026
Feb 22, 2026 - Feb 26, 2026
Mar 1, 2026 - Mar 5, 2026
Mar 8, 2026 - Mar 12, 2026

Seasonal Availability

Do you want to know if your event is during the high or low season? Check the season availability for this hotel.
High season
Aug 01 - Oct 31Jun 01 - Jul 31
Shoulder season
Mar 01 - May 31
Low season
Nov 01 - Dec 31Jan 01 - Feb 29

Meeting rooms

Total meeting space
14,000 sq. ft.
Largest room
4,222 sq. ft.
Space (private)
7,714 sq. ft.
Meeting rooms
5
Second largest room
3,845 sq. ft.
Exhibit space
14,000 sq. ft.
Space (semi-private)
3,845 sq. ft.
Space (outdoor)
1,420 sq. ft.
Explore Meeting Rooms
Explore Meeting Rooms
Find the perfect room with setup charts and interactive 3D floor plans.

Meeting space

Name
Room size
Maximum capacity
U-Shape
Banquet rounds
Cocktail rounds
Theater
Classroom
Boardroom
Crescent rounds (Cabaret)
Hollow square
4,222 sq. ft.
77 x 55 sq. ft.
375
50
280
375
380
140
36
210
68
1,953 sq. ft.
63 x 31 sq. ft.
150
40
120
150
150
88
32
80
44
570 sq. ft.
19 x 30 sq. ft.
48
16
32
40
48
24
20
24
20
646 sq. ft.
19 x 34 sq. ft.
60
20
40
60
56
24
20
30
24
323 sq. ft.
19 x 17 sq. ft.
10
-----
10
--
3,845 sq. ft.
-
---------

Guest rooms

Total guest rooms
173
Single (1 bed)
115
Double (2 beds)
33
Suites
18

Location

Getting Here

Distance from airport 13.8 mi
Parking in the area
Valet parking
( $45.00/day )
Street parking
Bus parking

Local Attractions

Enterprise Center
Enterprise Center
Recreation
6 blks
Check out Enterprise Center's calendar full of events! Go see a show, or experience a St Louis Blues Hockey game - there's almost always something going on at the Enterprise Center
Visit website
St Louis City SC
St Louis City SC
Recreation
5 blks
Catch an exciting match at St Louis City Stadium! Just a short walk from the hotel.
Visit website
St Louis Public Library
St Louis Public Library
Historical landmark
2 blks
Go on an architectural tour and take in the grandeur of this building from 1912.
Visit website
Stifel Theatre
Stifel Theatre
Recreation
3 blks
Catch a concert, some stand up, or just a tour in this historic theatre from 1934
Visit website
America's Center Convention Complex
America's Center Convention Complex
Convention center
7 blks
We are a short walk away from St Louis' convention center which features over 570,000 square feet of space. Grab a coffee from Good Press and fuel your convention filled day!
Visit website
City Museum
City Museum
Museum
4 blks
Is it a museum? Is it a playground? Is it both? Probably. We highly recommend taking the short walk over and finding out for yourself!
Visit website
Busch Stadium
Busch Stadium
Recreation
10 blks
The Cardinal's are just second in number of World Series wins in the MLB! Take a short walk down to Cardinal way, and pop in to one of the many restaurants and bars before heading into the stadium for a game.
Visit website
St Louis Aquarium
St Louis Aquarium
Recreation
6 blks
Go see the sea! With many galleries to venture through, the St Louis Aquarium always provides a memorable experience
Visit website

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All-Inclusive Group Dining When meeting planners book a corporate group event through Lip Smacking Foodie Tours, the entire group is assured a top-notch dining experience with three to four signature dishes at each restaurant. Our affordable tours are priced per person with tax and gratuities included. The only thing not included are drinks. However, a beverage package upgrade is available, which provides guests a signature cocktail at various stops. Build Your Network Our exclusive experiences provide the ultimate networking opportunities. At a typical sit-down dinner, you’re lucky to engage the person to the left and right of you. Because our tours take place at multiple restaurants, with walking in between, there are countless opportunities to interact with different people when you sit down at each venue and as you traverse along the way. Our experiences not only provide more ways to network, but a more convivial way to do so. Large Groups Welcome Lip Smacking Foodie Tours is ideal for groups, small or large. Our experiences can accommodate groups from as few as 1 to as many as 500 guests, making us an ideal choice for any corporate group event. Stress-Free Booking Process Booking a tour is stress-free and allows you to enjoy the company of your guests more easily. You’ll take comfort knowing that everything is taken care of from the moment the tour is booked to the minute it concludes. Since the menu is already set, you have nothing to worry about. Just remember to submit ahead of the tour date any dietary restrictions and food allergies for anyone in your group. Feel Like a VIP at Each Stop With Lip Smacking Foodie Tours, you and your group members never have to worry about waiting in line to get into a top restaurant or being shown to a less than desirable table. On our tours, everyone is treated like a VIP with immediate seating upon arrival. 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Tours Available from Day to Night With any corporate group experience, booking flexibility is key. Whether you desire a tour during business hours or early evening right after work, we can coordinate with you to provide options that fit your needs. Go for as Long or as Short as You Like Along with flexible scheduling, Lip Smacking Foodie Tours also provides a range of tour durations. Our shortest tour is about 2.5 hours; our longest is about 5 hours, with optional add-ons and incentives.
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Additional Information

Weblinks

21c Museum Hotel | St. Louis Frequently Asked Questions

Explore frequently asked questions from the 21c Museum Hotel | St. Louis regarding Health and Safety, Sustainability, and Diversity and Inclusion

Sustainable Practices

Please provide comments or a link to any publicly communicated 21c Museum Hotel | St. Louis's sustainability or social impact goals/strategy.
No response.
Does 21c Museum Hotel | St. Louis have a strategy that focuses on the elimination and diversion of waste (i.e. plastics, papers, cardboard, etc.)? If yes, please elaborate on your strategy of elimination and diversion of waste.
No response.

Diversity and Inclusion

For US hotels only, is 21c Museum Hotel | St. Louis and/or parent company certified as a 51% diverse owned business enterprise (BE)? If yes, please indicate which one of the following you are certified as:
No response.
If applicable, could you please provide a link to 21c Museum Hotel | St. Louis's public report on their commitments and initiatives related to diversity, equity, and inclusion?
No response.

Health and Safety

Were practices at 21c Museum Hotel | St. Louis developed based on health service recommendations from public governmental entities or private organizations? If Yes, please list which organizations were used to develop these practices.
No response.
Does 21c Museum Hotel | St. Louis clean and sanitize public areas and publicly accessible facilities (i.e. meeting rooms, restaurants, elevator banks, etc.)? If yes, describe any new measures that are taken.
No response.
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